Author(s)

Sommai Patitungkho^1*, Kingkaew Patitungkho²

¹Department of Chemistry, Buriram Rajabhat University, Buriram, Thailand.
²Department of Library and Information Science, Buriram Rajabhat University, Buriram, Thailand.

This work deals with the synthesis and physicochemical characterizations of a new group of novel retinoidal ligands and their metal complexes. Their in vitro anti-proliferative activities have shown that ligand L1 is effective against human breast cancer BT-20 and MCF-7 cell lines. At the same time, compound L2 exerts its effect on human prostate cancer PC-3 and human breast cancer MDA-MB-231 and MCF-7 cell lines respectively. The retinoid ligands exert their pleiotropic action toward retinoic acid receptors (RARs) than their metal complexes but all compounds exhibit concentration-dependent.

Metal Complexes, Cancers, Antioxidant, Hydrazone, Retinoid Receptors

Patitungkho, S. and Patitungkho, K. (2024) Synthesis and Physico-Chemical Characterizations of Novel Hydrazone Ligands and Their Metal Complexes against Hormone-Dependent and Independent Cancers. Open Journal of Medicinal Chemistry, 14, 1-13. doi: 10.4236/ojmc.2024.141001.