Author(s)

Carla Isabel Borré¹, Bethany Boyle², Kelsey Lynch², Anuradha Kanaparthi², Clifford Michael Csizmar², Daniel Philip Larson³, Matthew Dain Braithwaite⁴, Isla McKerrow Johnson⁴, Thomas Elmer Witzig⁴, Diego Armando Suarez^5*

¹Yale School of Public Health, Yale University, New Haven, USA.
²Department of Medicine, Mayo Clinic, Rochester, USA.
³Division of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, USA.
⁴Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, USA.
⁵Division of Community Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, USA.

Adult intussusception is rare, highly associated with a malignant lead point, and often requires emergent surgical management. We report the case of a 44-year-old male who presented with generalized abdominal pain and was found to have early ileocolic intussusception secondary to a large ileocecal mass. Biopsies of the mass and an enlarged cardiophrenic lymph node, as well as pleural fluid cytology were all consistent with Burkitt lymphoma (BL). Curiously, the patient’s abdominal exam was reassuring, and the intussusception and malignant bowel obstruction resolved over 36 hours with conservative management alone. With a Burkitt lymphoma international prognostic index (BL-IPI) score of 2, the patient proceeded to treatment with combination chemoimmunotherapy and attained a complete response after four cycles. There was no bowel perforation or recurrent intussusception throughout treatment. Thus, this report marks the first reported case of adult BL-associated intussusception to resolve with non-invasive management and establishes a precedent for conservative management in select patients.

Burkitt Lymphoma, Adult Intussusception, Prognostication

Borré, C. , Boyle, B. , Lynch, K. , Kanaparthi, A. , Csizmar, C. , Larson, D. , Braithwaite, M. , Johnson, I. , Witzig, T. and Suarez, D. (2023) Burkitt Lymphoma Presenting as Ileocolic Intussusception in an Adult. Open Journal of Blood Diseases, 13, 121-132. doi: 10.4236/ojbd.2023.134014.