Author(s)

Joseph Kangudia Mbaya, Damien Mbanzulu Pita Nsonizau, Nene Mbanzulu Nsolani, Gauthier Mesia

Department of Basic Sciences, Faculty of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.

The antimalarial phytomedicines, Manalaria® and Sirop Kilma®, also frequently used in Kinshasa at the start of pregnancy, would not have previously undergone embryotoxicity tests. This study aims to determine the embryotoxicity of Manalaria® and Sirop Kilma® on mice, Mus musculus. An experimental study in which 54 prepubescent mice were exposed during embryogenesis, including 16 mice to Manalaria®, 20 to Syrup Kilma® and 18 to Quinine. Careful observation by visual inspection and enlarged photography enabled the search for malformations in the exposed mice. As a result, all the mice exposed to the 3 antimalarials did not reveal visible malformations on visual inspection or on enlarged photography. In conclusion, under the experimental conditions of this study, no visible malformation was observed in mice exposed to the two phytomedicines in utero.

Embryotoxicity, Mus musculus, Manalaria, Syrup Kilma, Quinine

Kangudia Mbaya, J. , Mbanzulu Pita Nsonizau, D. , Mbanzulu Nsolani, N. and Mesia, G. (2023) Visible Malformations in Mice, Mus musculus Experimentally Exposed in Utero to Antimalarials (Manalaria®, Syrup Kilma® versus Quinine). Open Access Library Journal, 10, 1-9. doi: 10.4236/oalib.1110140.