Author(s)

Moctar Coulibaly^1*, Magara Samaké^2,3, Konaré Samba¹, Fofana Aboubacar Sidiki², Ossil Ampion Marc⁴, Batcho Jimmy⁴, Mansour Janette⁴, Seydou Sy^5,6, Hamadoun Yattara^5,6, Atabième Kodio⁵, Djénéba Maiga⁷, Sah Dit Baba Coulibaly⁸, Djénèba Diallo^5,6, Aboudou M. Dolo⁸, Moustapha Tangara^3,5, Nouhoum Coulibaly⁵, Kalilou Coulibaly⁸, Ibrahima Koné⁸, Saharé Fongoro^5,6

¹Nephrology Unit of Mali GAVARDO Hospital in Sebénicoro, Bamako, Mali.
²Nephrology Unit of the Fousseyni DAOU Hospital, Kayes, Mali.
³National Center for Scientific and Technological Research (CNRST), Bamako, Mali.
⁴Nephrology Department of the Soissons Hospital, Soissons, France.
⁵Nephrology and Hemodialysis Department of the UHC du Point G, Bamako, Mali.
⁶Faculty of Medicine of Bamako, Bamako, Mali.
⁷Nephrology Unit of Sikasso Hospital, Sikasso, Mali.
⁸Nephrology Unit of Somino DOLO Hospital, Mopti, Mali.

Renal damage secondary to paracetamol intoxication is rare, estimated between 1% and 2% of intoxication cases. Its pathophysiology is still debated, the clinical involvement consisting in an acute tubular necrosis with a good prognosis if it is rapidly treated. Renal damage can sometimes occur without prior hepatic damage, and the onset of renal manifestations is generally between the 2nd and 7th day after taking paracetamol. If its management remains exclusively symptomatic, its late onset can sometimes lead to serious metabolic complications. It is therefore important to systematically monitor renal function following paracetamol drug intoxication. We report the case of a 60-year-old male subject hospitalized for the management of voluntary drug intoxication (VDI) with paracetamol complicated by acute hepatocellular failure and acute renal failure. His management required extrarenal purification (hemodialysis) and the evolution was favorable with recovery ad integrumof renal function. Conclusion: Although less known and of unelucidated physiopathology, nephrotoxicity secondary to voluntary drug intoxication with paracetamol is a reality and can lead in extreme cases to the use of extrarenal purification technique (hemodialysis).

Acute Renal Failure, Paracetamol Intoxication, Hemodialysis

Coulibaly, M. , Samaké, M. , Samba, K. , Sidiki, F. , Marc, O. , Jimmy, B. , Janette, M. , Sy, S. , Yattara, H. , Kodio, A. , Maiga, D. , Coulibaly, S. , Diallo, D. , Dolo, A. , Tangara, M. , Coulibaly, N. , Coulibaly, K. , Koné, I. and Fongoro, S. (2022) Acute Renal Failure Secondary to Paracetamol Intoxication: A Case Report. Open Journal of Nephrology, 12, 235-240. doi: 10.4236/ojneph.2022.123024.