Author(s)

Fall Seynabou¹, Alioune Badara Diallo¹, Dibor Niang², El Hadji Daouda Niang¹, Khadim Sarr¹, Marième Lolita Camara¹, Abibatou Sall¹, Fatou Samba Ndiaye¹

¹Department of Hematology, Cheikh Anta Diop University, Dakar, Senegal.
²Department of Pathology, Gaston Berger University, Saint-Louis, Senegal.

Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma, characterized by high clinical and biological heterogeneity. Patients typically present with progressive lymphadenopathy, extranodal disease and may also experience fever, night sweats and unexplained weight loss. We report here the case of a 16-year-old female with osteoarticular pain, dizziness, and dyspnea on exertion. Clinical examination showed no lymphadenopathy. Complete blood count (CBC) revealed pancytopenia and marrow smears found to be hypocellular. Initial diagnosis favored secondary myelofibrosis. Diagnosis of bone marrow involvement by DLBCL was retained on bone marrow histology and immunohistochemistry which showed infiltration of large B lymphoid cells. The patient was treated by immunochemotherapy R-CHOP regimen. This case highlights a very rare and atypical circumstance of discovery of DLBCL with myelofibrosis as an initial symptom. Prognosis value of this presentation and management difficulties are also discussed.

Diffuse Large B-Cell Lymphoma, Myelofibrosis, Rituximab

Seynabou, F. , Diallo, A. , Niang, D. , Niang, E. , Sarr, K. , Camara, M. , Sall, A. and Ndiaye, F. (2022) A New Observation of Bone Marrow Involvement by Diffuse Large B-Cell Lymphoma Mimicking Myelofibrosis. Open Journal of Blood Diseases, 12, 39-44. doi: 10.4236/ojbd.2022.122004.