Author(s)

Fan Xu^1*, Xiao Li^2#, Xiaolei Yu¹, Qingshan Li¹, Wenxin Li¹, Xu Xiao³

¹Departments of Oncology, The Affiliated Hospital of Chengde Medical College, Chengde, China.
²Departments of Radiology, The Affiliated Hospital of Chengde Medical College, Chengde, China.
³Departments of Pharmacy, The Affiliated Hospital of Chengde Medical College, Chengde, China.

Objective: To study the effect of different doses of doxorubicin on H9C2 cells and to provide a reference for the clinical study of doxorubicin. Methods: Doxorubicin (1, 2, 4, 6, 10 ug/ml) was co-cultured with H9C2 cells for 6, 12 and 24 hours. The morphological changes of cells were observed, and the cell inhibition rates of different time and drug concentration were calculated. Results: Doxorubicin could inhibit the activity of cardiomyocytes in a dose-dependent manner from 1 to 10 ug/ml. Conclusion: A certain dose of doxorubicin has a toxic effect on cardiomyocytes and can cause cardiomyocyte necrosis and apoptosis.

H9C2 Cells, Doxorubicin, Cell Inhibition Rate

Xu, F. , Li, X. , Yu, X. , Li, Q. , Li, W. and Xiao, X. (2022) Effects of Different Doses of Doxorubicin on H9C2 Cells. Journal of Biosciences and Medicines, 10, 136-140. doi: 10.4236/jbm.2022.103014.