Author(s)

Baktygul Ernazarova¹, Taitokur Zhusubaliev¹, Zarylkan Asilbek kyzy¹, Aida Bakirova¹, Gulsara Zhusupbaeva², Orozby Akparalieva¹, Zhypargul Abdullaeva^3*, Nasibakhon Razykova¹, Asilkan Dzhumanazarova⁴, Galina Apryshko⁵, Alina Orozmatova¹

¹Department of Pharmacy and Medical-Biological Disciplines, Zhalal-Abad State University, Zhalal-Abad, Kyrgyzstan.
²Zhalal-Abad Scientific Center, South Department Academy of Sciences, Zhalal-Abad, Kyrgyzstan.
³Science and Research Department, Osh State University, Osh, Kyrgyzstan.
⁴Institute of Chemistry and Phytotechnology, National Academy of Sciences, Bishkek, Kyrgyzstan.
⁵National Medical Research Center of Oncology Named after N.N. Blokhin, Moscow, Russia.

Computer analysis of N-(β-D-galactopyranosyl)-thiosemicarbazide compounds by in silico method revealed high probability of antibacterial (antimycobacterial), anti-tuberculosis (antituberculosic), antiviral (Influenza), antitumor (antineoplastic) 9 > Pa > 0.5 and with a low probability of cytotoxic/cytostatic (cytostatic/cytotoxic) activities. An experimental study by in vitro and in vivo methods allowed us to conclude that studied new synthetic compound N-(β-D-galactopyranosyl)-thiosemicarbazide in the studied concentrations has a pronounced bactericidal and bacteriostatic effects.

Biological Activity, Synthesis, Urea, Carbohydrate, Compounds, Hyperurcemia, Ototoxicity, Testing, Toxicity, Anti Tuberculosis, Antitumor

Ernazarova, B. , Zhusubaliev, T. , Asilbek kyzy, Z. , Bakirova, A. , Zhusupbaeva, G. , Akparalieva, O. , Abdullaeva, Z. , Razykova, N. , Dzhumanazarova, A. , Apryshko, G. and Orozmatova, A. (2022) Study of Biological Activity and Toxicity of Thiosemicarbazides Carbohydrate Derivatives by in Silico, in Vitro and in Vivo Methods. Journal of Agricultural Chemistry and Environment, 11, 15-23. doi: 10.4236/jacen.2022.111002.