Author(s)

Simon Azonbakin^1*, Alfred Ouedraogo², Alexis Ouedraogo², Daniel Sewadouno¹, Arnaud Agbanlinsou¹, Yannick Goussanou¹, Marius Adjagba¹, Jules Alao³, Anatole Laleye¹

¹Laboratory of Histology-Reproductive Biology, Cytogenetics and Medical Genetics, Human Biology Unit, Faculty of Health Sciences, Abomey-Calavi University, Cotonou, Benin.
²Laboratory of Histology-Embryology, Cytogenetics and Reproductive Biology, Teaching Hospital of Bogodogo, Ouagadougou, Burkina Faso.
³Department of Pediatric and Medical Genetic, Faculty of Health Sciences, Abomey-Calavi University, Cotonou, Benin.

The chromosomal polymorphism defined by variations of some chromosomal regions of a person (the constitutive heterochromatin and the short arms of the acrocentric chromosomes (13 to 15 and 21 - 22)) sometimes highlighted problems with regard to their safety and their pathogenicity. Polymorphisms are usually found in the same family and transmitted in the dominant Mendelian. Chromosome 9 inversion is a frequent phenomenon that some cytogeneticists consider as a variant of normal. Despite its classification as a minor chromosome rearrangement which does not correspond to abnormal phenotypes, many reports have raised conflicting opinions as well, and its complete safety is controversial. 27 cases of inversion of chromosome 9 were identified in our laboratory. The main indications for karyotype of the case of inv (9) were congenital cardiopathy (18.5%), sex development disorders of (18.5%), down syndrome (18.5%), and infertility (14.8%). This study stood out the observations of many authors who highlighted the involvement of inv (9) in the genesis of several pathologies.

Inversion, Chromosome 9, Karyotype, Abnormality, Fertility

Azonbakin, S. , Ouedraogo, A. , Ouedraogo, A. , Sewadouno, D. , Agbanlinsou, A. , Goussanou, Y. , Adjagba, M. , Alao, J. and Laleye, A. (2021) Chromosome Polymorphism and Human Pathology: About 27 Cases of Chromosome 9 Inversion in the Beninese Population. Open Journal of Genetics, 11, 23-31. doi: 10.4236/ojgen.2021.113003.