Objective: To investigate the relationship between the four blood coagulation items and blood glucose and blood lipids in stroke patients with type 2 diabetes. Methods: According to whether they had type 2 diabetes, 134 stroke patients were divided into the observation group (n = 62) with stroke and type 2 diabetes and the control group without type 2 diabetes (n = 72), and the blood coagulation of each group was compared. Results: There was no significant difference in the four coagulation items between the two groups of patients, and hyperglycemia did not seem to have a significant effect on this. Conclusion: The coagulation changes in stroke patients may be greatly affected by the acute onset of stroke, and the impact of type 2 diabetes may be chronic and insignificant.