Predictive Value of miRNA-181a in Pediatric Acute Lymphoblastic Leukemia - Journal of Cancer Therapy

JCT > Vol.11 No.11, November 2020

Journal of Cancer Therapy

Volume 11, Issue 11 (November 2020)

ISSN Print: 2151-1934 ISSN Online: 2151-1942

Google-based Impact Factor: 0.35 Citations

Predictive Value of miRNA-181a in Pediatric Acute Lymphoblastic Leukemia ()

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DOI: 10.4236/jct.2020.1111057 417 Downloads 1,356 Views Citations

Author(s)

Asmaa El Desoky^1,2, Hosny Badrawy^2*, Dina Ismail Abd El Razik², Khaled F. Riad³, Omina N. Abdelhamid³, Eman Hassan²

Affiliation(s)

¹Translational Hematology and Oncology Research (THOR) Department, Learner Institute, Case Western Reserve University, Cleve-land, Ohio, USA.
²Department of Clinical Pathology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.
³Department of Pediatric Oncology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.

ABSTRACT

Background: Acute lymphoblastic leukemia (ALL), a common pediatric malignant neoplasia, showed high relapse rate after induction therapy. Some miRNAs have been shown to regulate normal hematopoiesis and their disruption could contribute to leukemogenesis: Recently, specific miRNA, including miR-181a, was shown to be involved in the pathogenesis of ALL, serving as a biomarker for diagnosis and relapse of ALL. Aim of the Study: To evaluate miR-181a expression level as a predictive marker for children with acute lymphoblastic leukemia. Patients and Methods: 40 pediatric ALL patients were included in this study. miR-181a expression was assessed at diagnosis before start of treatment. Samples were either peripheral blood or bone marrow aspirate sample. Patients were evaluated clinically and laboratory after the induction therapy. Results: The remission rate was significantly higher in patients with high miR-181a expression compared to those with low expression (p < 0.001). Conclusion: The expression level of miR-181a was significantly higher in remission group than in non-remission group was and predict good response to induction therapy.

KEYWORDS

miR-181a, Micro-RNA, ALL

Share and Cite:

Desoky, A. , Badrawy, H. , Razik, D. , Riad, K. , Abdelhamid, O. and Hassan, E. (2020) Predictive Value of miRNA-181a in Pediatric Acute Lymphoblastic Leukemia. Journal of Cancer Therapy, 11, 673-682. doi: 10.4236/jct.2020.1111057.

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