Entrepreneurship plays a vital role in promoting the development of the economy and society. Researchers had paid more and more attention to entrepreneurship education and courses in universities. The traditional infusing entrepreneurial classroom cannot achieve entrepreneurship education’s objectives of the audience’s innovative spirit, entrepreneurial quality, and entrepreneurial ability. The author designed interactive teaching forms such as case study, competition teaching mode, and question-based teaching mode to promote the implementation of interactive teaching of college students’ entrepreneurship education based on the interactive teaching theory and combined with college students’ classroom characteristics’ entrepreneurship education in pre-class preparation, in-class control, and after-class correction. Through several rounds of practice by the teaching team, the interactive entrepreneurship course has achieved an excellent teaching effect. Students like the interactive teaching mode and give a high evaluation of the system.