Author(s)

Chioma Donlawson^1*, Daniel Okechukwu Nweneka¹, Kingsley John Orie², Reminus Okah¹

¹Department of Science Laboratory Technology, Captain Elechi Amadi Polytechnic, Rumuola, Nigeria.
²Department of Pure and Industrial Chemistry, University of Port Harcourt, Port Harcourt, Nigeria.

1-((2-Carbamoylguanidino)(furan-2-ylmethyl)urea was synthesised by coupling purified furfural with urea. The compound was characterized by GC-MS, FTIR, and ¹H-NMR. The pathogens, Escherichia coli, Salmonella typhi, Staphylococcus aureus and Bacillus subtilis were isolated and screened with different concentrations of 1-((2-carbamoylguanidino)(furan-2-ylmethyl)urea. All the pathogens were susceptible to the synthesized compound except Bacillus subtilis. Due to this broad spectrum of activity, 1-((2-Carbamoylguanidino)(furan-2-ylmethyl))urea) can be use for various medicinal purposes and is therefore encouraged for the development of a novel drug in future.

Furfural, 1-((2-Carbamoylguanidino)(furan-2-ylmethyl)urea, Bioactivity

Donlawson, C. , Nweneka, D. , Orie, K. and Okah, R. (2020) Synthesis and Bioactivity of 1-((2-Carbamoylguanidino)(furan-2-ylmethyl)urea. American Journal of Analytical Chemistry, 11, 280-288. doi: 10.4236/ajac.2020.117022.