ADAMTS-8 Activity in Synovial Cells in Patients with Rheumatoid Arthritis - Open Journal of Rheumatology and Autoimmune Diseases

OJRA > Vol.10 No.3, August 2020

Open Journal of Rheumatology and Autoimmune Diseases

Volume 10, Issue 3 (August 2020)

ISSN Print: 2163-9914 ISSN Online: 2164-005X

Google-based Impact Factor: 0.26 Citations

ADAMTS-8 Activity in Synovial Cells in Patients with Rheumatoid Arthritis ()

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Download as PDF (Size: 510KB) PP. 125-131

DOI: 10.4236/ojra.2020.103014 563 Downloads 1,350 Views Citations

Author(s)

Murat Baloğlu^1*, Engin Deveci², Şenay Deveci³

Affiliation(s)

¹Department of Physical Therapy and Rehabilitation, Diyarbakir Gazi Yasargil Education and Research Hospital, Diyarbakir, Turkey.
²Department of Histology and Embryology, School of Medicine, Dicle University, Diyarbakir, Turkey.
³Department of Medical Documentation, Atatürk Health Vocational School, Diyarbakir, Turkey.

ABSTRACT

Rheumatoid arthritis (RA), chronic, autoimmune causing joint stiffness, pain, fatigue and functional disorders is a disease. The aim of this study is to investigate the presence of ADAMTS-8 expression in cells in synovial fluid in rheumatoid arthritis patients. Patients with active RA were aspirated with arthro synthesis from the knee joint. Blood samples were taken from the patients at the same time, plasma samples were separated. Patients with sinovial fluid treated between 2019-2020 year in the Gazi Yaşargil Hospital Physical Therapy and Rehabilitation Clinic were involved in the study that was consulted with knee pain and difficulty in performing their daily activities. Informed consent form was obtained from all of the patients (10 RA and 10 patients). CRP, RF and ESH results were statistically evaluated in patients with Control and Rheumatoid arthritis. CRP, RF and ESH results were statistically evaluated in patients with Control and Rheumatoid arthritis. In patient samples with Rheumatoid arthritis, degeneration in synovial cells was observed in some nuclei in the form of pycnosis and apoptotic. ADAMTS-8 expression in the form of aggregates in synovial cells was found to be positive. It was observed that rheumatoid arthritis increased apoptotic change in synovial cells. ADAMTS8 in synovial cells in rheumatoid arthritis cases may cause a significant increase in apoptosis levels by suppressing some signal pathways, and predicts that apoptosis induction may play a role in the inhibition of ADAMTS8-mediated synovial cell proliferation.

KEYWORDS

Romatoid Artrit, Sinovial Fluid, ADAMTS-8

Share and Cite:

Baloğlu, M. , Deveci, E. and Deveci, Ş. (2020) ADAMTS-8 Activity in Synovial Cells in Patients with Rheumatoid Arthritis. Open Journal of Rheumatology and Autoimmune Diseases, 10, 125-131. doi: 10.4236/ojra.2020.103014.

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