International Journal of Clinical Medicine

Volume 10, Issue 4 (April 2019)

ISSN Print: 2158-284X   ISSN Online: 2158-2882

Google-based Impact Factor: 0.62  Citations  h5-index & Ranking

Discussion on the Effectiveness of Elevating HDL-C in Treating Cardiovascular Diseases of Patients with Type 2 Diabetes Mellitus

HTML  XML Download Download as PDF (Size: 356KB)  PP. 293-305  
DOI: 10.4236/ijcm.2019.104022    548 Downloads   810 Views  
Author(s)

ABSTRACT

High density lipoprotein protects cardiovascular diseases and reduces the risk of cardiovascular diseases through cholesterol reverse transport and other mechanisms. High-density lipoprotein cholesterol (HDL-C) is an independent predictor of negative events in cardiovascular diseases. Low concentration of HDL-C indicates abnormal regulation of HDL anabolism. Various proteins and receptors such as cholesteryl ester transfer protein (CETP) are involved in HDL anabolism. Type 2 Diabetes Mullitu and its related metabolic syndrome, chronic inflammation as well as oxidative stress not only affect the proteins and receptors related to HDL anabolism, but also affect their functional changes, making HDL change from anti-inflammatory, antioxidant, protecting endothelial cell function to pro-inflammatory, pro-oxidative and pro-endothelial cell apoptosis. This article will describe the relationship between HDL-C, type 2 diabetes and cardiovascular diseases from the effects of T2DM on HDL anabolism and function, and further explore the effectiveness of elevating HDL-C in treating cardiovascular diseases of patients with type 2 diabetes.

Share and Cite:

Wang, S. and Wang, L. (2019) Discussion on the Effectiveness of Elevating HDL-C in Treating Cardiovascular Diseases of Patients with Type 2 Diabetes Mellitus. International Journal of Clinical Medicine, 10, 293-305. doi: 10.4236/ijcm.2019.104022.

Cited by

No relevant information.

Copyright © 2021 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.