Antidepressant-Like Activity of Methanolic Extract of the Seeds of Trachysperum ammi in Swiss Albino Mice ()
ABSTRACT
Trachysperum ammi has been traditionally used for the treatment of neurological disorders
such as depression and anxiety. To date, T.
ammi has reported for its chemical constituents in different diseases
condition. The traditional evidence convinced us to perform the
antidepressant-like activity of methanolic extract of Trachysperum ammi (META). The antidepressant activity of META
assessed by using forced swimming test (FST), tail suspension test (TST), and
locomotor activity test. The seed parts of META at doses level of 50, 100 and
200 mg/kg body weight administered orally to examine the CNS stimulants
activity test in mice behavioral models. Here, we reported that META
significantly reduced immobility time in the FST after repeated administration
of 50, 100 and 200 mg/kg to mice for 14 days. The intensity of immobility significantly
reduced at all of the doses (p < 0.05) whereas, we were found the strongest
effect observed at 200 mg/kg. The antidepressant-like effect of META caused the
reduction (p < 0.05) in the immobility in TST of mice when orally
administered with 50, 100 and 200 mg/kg for 14 days, respectively. Additionally,
we were executed locomotor activity test to check the motor stimulating
activity. META has employed at a dosage of 50, 100 and 200 mg/kg for 14 days,
the results have found that 50 mg/kg produced the locomotion effects as similar to the
control group. Interestingly, the locomotion, rearing, and defecation
significantly (p < 0.05) increased at the dosage of 100 and 200 mg/kg of META. Our
present findings suggest that the seed parts of Trachysperum ammi may possess antidepressant-like activity
which may use as a supportive treatment to management of neurological
disorders.
Share and Cite:
Rahman, M. , Ali, M. , Sharif, M. , Sajon, S. , Mannan, M. and Shahed-Al-Mahmud, M. (2018) Antidepressant-Like Activity of Methanolic Extract of the Seeds of
Trachysperum ammi in Swiss Albino Mice.
Pharmacology & Pharmacy,
9, 503-514. doi:
10.4236/pp.2018.912039.