Anti-Aging Effect of Cynara cardunculus L. var. Cynara scolymus L. Extract in D-Galactose-Induced Skin Aging Model in Rats - Pharmacology & Pharmacy

PP > Vol.9 No.10, October 2018

Volume 9, Issue 10 (October 2018)

ISSN Print: 2157-9423 ISSN Online: 2157-9431

Google-based Impact Factor: 0.70 Citations h5-index & Ranking

Anti-Aging Effect of Cynara cardunculus L. var. Cynara scolymus L. Extract in D-Galactose-Induced Skin Aging Model in Rats ()

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DOI: 10.4236/pp.2018.910032 1,214 Downloads 2,563 Views Citations

Author(s)

Galina Sukoyan^1*, Edisher Tsivtsivadze¹, Veronika Golovach¹, Tamara Kezeli², Natalya Demina³

Affiliation(s)

¹International Center of Introduction of New Biomedical Technology, Tbilisi, Georgia.
²Department of Pharmacology, Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia.
³Department of Pharmacy Technology of Federal State Autonomous Educational Institution of Higher Education, I. M. Sechenov of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.

ABSTRACT

The aim of the study was to evaluate the efficacy of 2% Cynara scolymus L. extracts in reverse disturbances of collagen metabolism and inflammation in D-galactose induced skin aging model in rats. D-galactose induced aging reproduced in 48 animals of main group, and 12 rats in control group. All animals in main group were randomized for 4 groups: I. aging + saline, II - IV. different manufacturers 2% artichoke extracts (with content of chlorogenic acid < 2.5%) in a dose of intradermal injection 0.13 mg twice at weeks during 4 weeks. Influence of artichoke extracts restored skin relative weight and led to an increase of solubility in neutral salt and acid, and decreased pepsin solubility collagen fraction, restored the hexosamine/collagen (hydroxyproline) ratio and decreased the activity of nuclear transcription factor (NF-kB). Local prolonged treatment with artichoke extracts improved collagen metabolism and attenuated the progression of inflammation in D-galactose induced skin aging model.

KEYWORDS

Skin, Aging, Collagen, Pure Water Cynara cardunculus L. var. Cynara scolymus L. Extract, Nuclear Transcription Factor Kappa B

Share and Cite:

Sukoyan, G. , Tsivtsivadze, E. , Golovach, V. , Kezeli, T. and Demina, N. (2018) Anti-Aging Effect of Cynara cardunculus L. var. Cynara scolymus L. Extract in D-Galactose-Induced Skin Aging Model in Rats. Pharmacology & Pharmacy, 9, 428-439. doi: 10.4236/pp.2018.910032.

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