Author(s)

Bambang Suprayogi Resi Utomo¹, Mochammad Hatta², Sutji Pratiwi³, Muhammad Nasrum Massi⁴, Lina Marlina¹, Erica Gilda Minawati Simanjuntak⁵

¹Department of Ear Nose and Throat, Faculty of Medicine, Indonesia Christian University of Jakarta, Jakarta, Indonesia.
²Molecular Biology and Immunology Laboratory for Infection Diseases, Faculty of Medicine, University of Hasanuddin, Makassar, Indonesia.
³Department of Ear Nose and Throat, Faculty of Medicine, University of Hasanuddin, Makassar, Indonesia.
⁴Department of Microbiology, Faculty of Medicine, University of Hasanuddin, Makassar, Indonesia.
⁵Department of Anesthesiology, Faculty of Medicine, Indonesia Christian University of Jakarta, Jakarta, Indonesia.

Background: A new concept in understanding allergic diseases is regulatory T cells (Tregs), which control the immune reaction caused by Th2 cytokine production. Forkhead Box Protein 3 (FoxP3) is a marker that has a critical role in the development and function of Tregs. Some studies found differences in FoxP3 level and in Tregs capacity to control immune reactions in allergic diseases. The aim of this study was to investigate FoxP3 level in Allergic rhinitis (AR) patients compared to atopic and healthy/normal persons in Jakarta. Methodology: This study used observation to analyze the level of FoxP3 in AR, atopic and healthy/normal persons, and used ELISA to measure the FoxP3 level. Results: The study had sixty participants divided into three groups: 21 in the Normal group, 16 in the Atopic group, and 23 in the AR group. The mean FoxP3 levels were 0.81 ± 0.35 in the normal group, 3.42 ± 0.15 in the atopic group, and 3.40 ± 0.13 in the AR group. Statistical analysis with Mann-Whitney tests indicated significant differences, with AR and atopic groups having higher FoxP3 levels than the normal group, (p = 0.001), and no statistically significant differences between the AR and atopic groups, (p = 0.92). Conclusion: Our study results suggested that FoxP3 was active in the control of inflammatory processes due to allergies, and decrease level of FoxP3 indicated severe AR, but suggested another mechanism caused differences in the clinical phenotypes of AR and atopic patients, despite them having equally high levels of FoxP3.

Allergic Rhinitis, Atopic, Regulator T Cells, FoxP3, ELISA

Utomo, B. , Hatta, M. , Pratiwi, S. , Massi, M. , Marlina, L. and Simanjuntak, E. (2018) Analysis of Forkhead Box Protein-3 (Foxp3) in Allergic Rhinitis Patients. International Journal of Otolaryngology and Head & Neck Surgery, 7, 228-236. doi: 10.4236/ijohns.2018.74024.