Oxidative Stress and Dyslipidemia as Indicators of Pathogenesis of Preeclampsia in Pregnant Sudanese Women - Journal of Biosciences and Medicines

JBM > Vol.6 No.7, July 2018

Journal of Biosciences and Medicines

Volume 6, Issue 7 (July 2018)

ISSN Print: 2327-5081 ISSN Online: 2327-509X

Google-based Impact Factor: 0.51 Citations

Oxidative Stress and Dyslipidemia as Indicators of Pathogenesis of Preeclampsia in Pregnant Sudanese Women ()

HTML XML

Download as PDF (Size: 1051KB) PP. 48-65

DOI: 10.4236/jbm.2018.67005 979 Downloads 2,585 Views Citations

Author(s)

Hafiz Ahmed Hobiel¹, Hani Yousif Zaki Tadros²

Affiliation(s)

¹Department of Biochemistry, Faculty of Medicine and Health Sciences, West Kordofan University, Elnihoud, Sudan.
²Department of Biochemistry and Nutrition, Faculty of Medicine, Gezira University, Medani, Sudan.

ABSTRACT

Background: Preeclampsia (PE) still ranks as one of obstetrics major problems and is still a serious threat, mainly in underdeveloped countries where its incidence and mortality rates are higher and is a major cause of preterm birth and intra-uterine growth restriction. Aim: To evaluate the role of oxidative stress and dyslipidemia as indicators of pathogenesis and risks of preeclampsia in pregnant Sudanese women attending Wad-Medani Obstetrics and Gynecology Teaching Hospital. Material and Method: This was a cross-sectional (case-control) study carried out in preeclamptic pregnant Sudanese women attending Wad-Medani Obstetrics and Gynecology Teaching Hospital. A total of 208 pregnant women were enrolled in the study, 111 patients and 97 women with normal pregnancy as controls; pregnant women suffering from any systemic or endocrine disorder were excluded. We compared the serum levels of total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, nitric oxide, and total antioxidant capacity between preeclamptic and controls. Result and Conclusion: Pregnant women with increase in BMI have a higher chance of developing PE. Low level of high-density lipoprotein cholesterol and high level of low-density lipoprotein cholesterol define that dyslipidemia increases the risk of PE. Decreased levels of NO and TAC might reflect the oxidative stress and likely contribute to the pathophysiological mechanisms of PE.

KEYWORDS

Preeclampsia, Oxidative Stress, Total Antioxidant Capacity, Nitric Oxide, Dyslipidemia

Share and Cite:

Hobiel, H. and Tadros, H. (2018) Oxidative Stress and Dyslipidemia as Indicators of Pathogenesis of Preeclampsia in Pregnant Sudanese Women. Journal of Biosciences and Medicines, 6, 48-65. doi: 10.4236/jbm.2018.67005.

Cited by

[1]	Evaluation of endothelial dysfunction and pregnancy outcomes in preeclampsia
	2021

[2]	High prevalence of vitamin D deficiency among normotensive and hypertensive pregnant women in Ghana
	2021

[3]	GANGGUAN FUNGSI GINJAL PADA IBU HAMIL PREEKLAMPSIA BERAT DENGAN DISLIPIDEMIA DI RSUD KELAS B SERANG
	2020

[4]	Protective Effect of Pravastatin on Offspring Development of Preeclampsia Model Rats by Inhibiting TLR4 Signaling Pathway and Sterol Synthesis.
	2020

Journals Menu

Follow SCIRP

	+1 323-425-8868
	customer@scirp.org
	+86 18163351462(WhatsApp)
	1655362766

	Paper Publishing WeChat

Journals Menu

Home

About SCIRP

Service

Policies