Author(s)

Kanako Ogura^1*, Toshiharu Matsumoto¹, Asumi Sakaguchi¹, Hiroko Onagi¹, Ayako Ura¹, Taijiro Kosaka², Toshiaki Kitabatake², Kuniaki Kojima², Toshio Morizane³

¹Departments of Diagnostic Pathology, Juntendo University Nerima Hospital, Tokyo, Japan.
²Breast Surgery, Juntendo University Nerima Hospital, Tokyo, Japan.
³Japan Council for Quality Health Care, Tokyo, Japan.

Aims: The reproducibility of Ki-67 between core-needle biopsies and surgical materials has not been well documented in the literature, although the concordance affects the utility of the Ki-67 labeling index based on the core-needle biopsy materials, which indicates the need for preoperative chemotherapy. The aim of this study was to reveal the reproducibility of Ki-67 between both materials and the cause of discrepancies. Methods and Results: We analyzed 137 cases of invasive carcinoma of the breast and the compared Ki-67-labeling index between core-needle biopsy and surgical materials. The Ki-67-labeling index of biopsy and surgical specimens ranged from 1% to 85% (median: 13%) and 1% to 80% (median: 12%), respectively. The discrepancy of Ki-67-labeling ranged from 0% to 55% (median: 4%) and could be calculated by the tumor size, hot spots of surgical materials, a high Ki-67-labeling index based on the core-needle biopsy materials, and the total length of core needles, respectively. Conclusions: The concordance rate of the Ki-67-labeling index between core-needle biopsies and surgical materials was favorable, so we can use each Ki-67-labeling index of core-needle biopsies as a marker for preoperative chemotherapy. Factors affecting the index discrepancy were hot spots, a high Ki-67-labeling index, and the total length of biopsy material. Judgements on the subtypes and clinical procedures of invasive breast carcinoma could be made comprehensively based on not only the Ki-67-labeling index but also the existence of hot spots and histological grade.

Ki-67, Core-Needle Biopsy, Breast, Invasive Carcinoma, Hot Spots

Ogura, K. , Matsumoto, T. , Sakaguchi, A. , Onagi, H. , Ura, A. , Kosaka, T. , Kitabatake, T. , Kojima, K. and Morizane, T. (2018) Favorable Reproducibility of Ki-67-Labeling Index between Core Needle Biopsy and Surgical Materials in Mammary Carcinoma: Reproducibility Influenced by Hot Spots, a High Ki-67 Labeling Index, and the Total Length of Biopsy Material. Open Journal of Obstetrics and Gynecology, 8, 647-659. doi: 10.4236/ojog.2018.87069.