Prognostic Factors and Treatment Outcome in 178 Locally Advanced Cervical Cancer Patients ()
Affiliation(s)
1Radiation Oncology Department, Kartal Dr Lutfi Kirdar Training and Research Hospital, Saglik Bilimleri University, Istanbul, Turkey.
2Radiation Oncology Department, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.
3Radiation Oncology Department, Bezmialem Vakif University, Istanbul, Turkey.
ABSTRACT
Background: To evaluate local control, survival, radiation side
effects and treatment outcome in locally advanced cervical cancer patients. Materials and Methods: Among 2006-2011, 178 patients with locally advanced cervical cancer were
treated with chemoradiotherapy +/- radiotherapy and high dose rate (HDR) brachytherapy. Follow-up was
complete for all patients. Concomitant chemotherapy was not administered in 44
patients due to renal impairments and ECOG of 2 - 3. Results: The median follow-up period was 34.5 months (range, 5 to
93) and 42 months (range, 14 to 93 months) for alive patients. Five years
local-regional control, progression-free survival and overall survival rates
were 87.8%, 58.9% and 67.3% in all patients, respectively. In this retrospective
study young age, tumor diameter, stage, presence of residual tumor and
administration of chemotherapy were effected in survival analysis. The
parameters which affected the complete response of patients were defined as
presence of concomitant chemotherapy and number of courses <5. Central
region recurrence rate was defined higher in the group with treatment duration
of 9 weeks and higher (p =
0.044). Conclusion: Primary chemoradiotherapy +/- radiotherapy achieved a satisfactory rate of
local control and survival rates with acceptable complications in locally
advanced cervical cancer. Concomitant chemotherapy and treatment duration were
the important prognostic factors for completed response locally advanced
cervical cancers.
Share and Cite:
Yetmen Dogan, O. , Dogan Eren, M. , Ozdemir Dag, S. and Mayadağli, A. (2018) Prognostic Factors and Treatment Outcome in 178 Locally Advanced Cervical Cancer Patients.
Open Journal of Obstetrics and Gynecology,
8, 485-496. doi:
10.4236/ojog.2018.85055.
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