Author(s)

Pascal Ngoy Wakumilua¹, Donatien Kayembe Nzongola-Nkasu², Jean Pierre Elongi Moyene^3*, Dophie Tshibuela Beya², Mamy Ngole Zita², Jeremie Muwonga Masidi², Mireille Nganga Nkanga², Guelord Mukiapini Luzolo², Daddy Kabamba Numbi²

¹Département de Sciences de la Santé/Faculté de Sciences/Université Pédagogique Nationale, Kinshasa, RD Congo.
²Département de Biologie Médicale, Service de Biologie Cliniques, Cliniques Universitaires de Kinshasa, Kinshasa, RD Congo.
³Département de Gynécologie-Obstétrique, Hopital Général de Référence de Kinshasa, Kinshasa, RD Congo.

Goal: The present study aimed to determine the profile of seric calcium and magnesium in pre-eclamptic and eclamptic pregnant women of Kinshasa province in the Democratic Republic of Congo where preeclampsia is characterized not only by a high incidence, but also by a seasonal variation probably related to nutritional intake. Study Design: This is a case-control study that took place during the period from September 2014 to March 2015 in four quaternary and tertiary maternity hospitals in Kinshasa. A total of 113 healthy pregnant women (controls) and 112 pre-eclamptic and eclamptic pregnant women (cases) were included in this study. Seric calcium and magnesium were measured in all these gravidas by the principle of spectrophotometry with a HUMALYSER Primus semi-automaton. Results: The mean age of those gravidas was 26.8 ± 6.3 years (26.7 vs 26.9, p = 0.11). The majority of these gravidas were primiparous. The mean gestational age in both groups was 31.35 ± 0.9 weeks (32.1 vs 30.6, p = 0.21). The average seric calcium value was 4.47 ± 0.23 mEq /L in healthy pregnant women compared to 3.80 ± 0.71 mEq/l in pre-eclamptics (P < 0.001). The mean of seric magnesium was 1.56 ± 0.15 mg/dL in healthy pregnant women compared to 1.20 ± 0.41 mg/dL in pre eclamptics (P < 0.001). Seric calcium and magnesium values were low in the pre-eclamptic group and lower in the eclamptic group (P < 0.001). Conclusion: This study establishes a relationship between the low concentration of seric calcium and magnesium with pre-eclampsia and eclampsia, which could be one of the determinants of the high prevalence and seasonality of the disease in Kinshasa.

Seric, Calcium, Magnesium, Preeclampsia, Kinshasa

Wakumilua, P. , Nzongola-Nkasu, D. , Moyene, J. , Beya, D. , Zita, M. , Masidi, J. , Nkanga, M. , Luzolo, G. and Numbi, D. (2018) Seric Calcium and Magnesium in Normal and Pre Eclamptic Pregnant Women: A Case-Control Study in Kinshasa, D R Congo. Open Journal of Obstetrics and Gynecology, 8, 408-415. doi: 10.4236/ojog.2018.84046.