Anti-Aminoacyl tRNA Synthetases Antibodies in Japanese Patients with Interstitial Lung Disease ()
Affiliation(s)
1Division of Rheumatology, Department of Internal Medicine, Tokai University, School of Medicine, Isehara, Japan.
2Medical Education Center, Keio University School of Medicine, Tokyo, Japan.
3Division of Pulmonary Medicine, Department of Internal Medicine, Tokai University, School of Medicine, Isehara, Japan.
4Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan.
ABSTRACT
Objectives: In the present study, we have sought to establish the clinical and
immunological characteristics of Japanese patients with interstitial lung
disease (ILD). Methods: Serum samples from 35 patients of ILD were
screened for autoantibodies using RNA and protein immunoprecipitation assays.
Patients with or without serum antibodies to aminoacyl tRNA synthetases (ARS)
were assessed clinically and compared. Results: Sera from 12 of 35 (34%)
patients with ILD (mean age at onset = 49.7 yrs; range 27 - 65 yrs) were found
to contain anti-ARS antibodies (anti-EJ: 3 patients; anti-OJ: 2 patients;
anti-PL-12: 3 patients; anti-KS: 4 patients). Nine of the 12 (75%) were female.
Six (50%) had Raynaud’s phenomenon, 5 (42%) had arthralgia/arthritis and four
(33%) had rheumatoid factor. Lung biopsy specimens of 8 patients with anti-ARS
antibodies were examined histologically in detail. The following was
determined: Two patients had usual interstitial pneumonia; 3 had non-specific
interstitial pneumonia; one had organizing pneumonia; one had lymphocyte
interstitial pneumonia and the remaining patient had desquamative interstitial
pneumonia. Age at disease onset was significantly lower and the frequency of
Raynaud’s phenomenon was significantly greater in these patients compared to
anti-ARS-negative patients (49.7 yrs vs. 62.6 yrs, p = 0.004; 50% vs. 4%, p = 0.003,
respectively). Conclusions: These results indicate that the presence of
anti-ARS autoantibodies correlates with ILD without definite diagnosis of
connective tissue diseases as well as polymyositis/dermatomyositis (PM/DM) with
ILD in Japanese patients.
Share and Cite:
Sato, S. , Hirakata, M. , Asano, K. and Kuwana, M. (2018) Anti-Aminoacyl tRNA Synthetases Antibodies in Japanese Patients with Interstitial Lung Disease.
Open Journal of Rheumatology and Autoimmune Diseases,
8, 34-42. doi:
10.4236/ojra.2018.81003.
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