Author(s)

Hao Xu, Weicheng Wang, Xiaoming Zhang, Yi Zhou, Jing Zheng, Cui Yang, Lin Yang^*

Sichuan Key Laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.

Gastric cancer ranks as the fifth most common malignant tumor worldwide and is the third most common cause of cancer-related death. For advanced gastric cancer (AGC), neoadjuvant chemotherapy (NAC) can reduce its stage, increase the rate of radical resection, improve response to treatment, reduce the risk of local recurrence and improve survival rate. Regional arterial infusion chemotherapy (RAIC) is a form of NAC that involves directly injecting chemotherapeutic drugs into the tumor site through the tumor-feeding artery. RAIC increases the local drug concentration around the tumor, thereby improving the therapeutic responses and reducing the adverse effects of the drugs. In recent years, RAIC has attracted increasing attention. This article summarizes the basic principles, procedure, chemotherapy regimens, adverse drug reactions and complications, clinical applications and response evaluation of RAIC in the treatment of AGC.

Gastric Cancer, Neoadjuvant Chemotherapy, Regional Arterial Infusion Chemotherapy

Xu, H. , Wang, W. , Zhang, X. , Zhou, Y. , Zheng, J. , Yang, C. and Yang, L. (2018) Application of Regional Arterial Infusion Chemotherapy in Advanced Gastric Cancer. Journal of Cancer Therapy, 9, 118-129. doi: 10.4236/jct.2018.92013.