Is Osteosarcoma between the Two Peak Ages Different? ()
ABSTRACT
Background: Unlike two known peak age groups (10 - 14 and older than 65 years of age), there was
relatively scant attention in osteosarcoma patients between them, and previous
reports had analyzed other than Asians. Therefore we conducted this study with
Korean patients and focused on 20 - 40 years of age, then investigated age-specific or
race-specific meaningful outcomes. Materials and Methods: 379 patients
who were newly diagnosed as osteosarcoma in two Korean major cancer hospitals
from September 1986 to July 2015 with more than 2-year follow-up were retrospectively
studied. There were 290 patients with 20 - 40 years of age, 60 patients aged 19 or younger, and
29 patients aged 41 or older. Age at diagnosis, gender, location of primary
lesion, metastasis at diagnosis, histologic subtypes, histologic response were
analyzed as prognostic factors by overall survival (OS) and event-free survival (EFS) rates. Results: Primary pelvic lesion
and poor histologic response were significantly unfavorable prognostic factors,
but not age-specific. However, proportion of metastasis at diagnosis was
significantly highest in 20 - 40 years of age group. For the age at diagnosis,
older patients presented poorer 5-year OS and EFS rates, but for 10-year, 20 - 40 years of age group showed unusually better
prognosis than younger age’s, with statistic significance in OS rates but not
in EFS rates. Conclusion: Osteosarcoma patients with 20 - 40 years of age in Korea presented relatively better
prognosis after longer-term 10-year despite their late diagnosis causing more
metastasis at diagnosis, which emphasized expedite diagnosis and appropriate treatment to
expect much better prognosis than peak age groups.
Share and Cite:
Kim, T. , Chung, H. , Cho, W. , Jeon, D. and Chung, S. (2018) Is Osteosarcoma between the Two Peak Ages Different?.
Journal of Cancer Therapy,
9, 64-78. doi:
10.4236/jct.2018.91008.
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