Aberrant Light-Induced Depression is Associated with Impaired Sensorimotor Gating in Mice ()
ABSTRACT
Mice subjected to an irregular light-dark cycle are
known to lose their capacity to synchronize their behavioral rhythm to
environmental light, and to show endophenotypes related to depressive
disorders. Here we observed that a susceptible strain of mice (C3H/HeJ)
subjected to an irregular 3.5 hr:3.5 hr light-dark cycle showed
an enhanced acoustic startle reflex and deficits in prepulse inhibition. As
impaired sensorimotor gating is associated with the onset of a variety of
mental disorders such as schizophrenia and major depressive disorder, irregular
environmental light without circadian photo-entrainment may cause stress that
has the potential to be involved in humans’ susceptibility to neuropsychiatric
abnormalities.
Share and Cite:
Haga, T. , Toei, J. , Mitsui, K. , Ohtsuji, M. , Kodera, Y. , Osada, K. and Nishimura, H. (2018) Aberrant Light-Induced Depression is Associated with Impaired Sensorimotor Gating in Mice.
World Journal of Neuroscience,
8, 1-9. doi:
10.4236/wjns.2018.81001.
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