Journal of Crystallization Process and Technology

Volume 7, Issue 4 (October 2017)

ISSN Print: 2161-7678   ISSN Online: 2161-7686

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Thermal Decomposition Kinetics of Ursodeoxycholic Acid Drug Crystal

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DOI: 10.4236/jcpt.2017.74006    877 Downloads   1,441 Views  Citations


The crystallization of ursodeoxycholic acid drug crystals in gel by reduction of solubility method is the first of its kind to be reported in literature. Monoclinic crystalline form of the structure was confirmed using single crystal X-ray diffraction analysis. This report deals with the kinetic analysis made from the thermogravimetric analysis/differential thermal analysis (TGA/DTA) data using Coats-Redfern (CR) relation. Thermodynamic parameters were also determined. Arrhenius equation for ursodeoxycholic acid was derived as k = 3.10 × 1010 e172581/RT mol1s1.

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Ramukutty, S. , Jeyasudha, R. and Ramachandran, E. (2017) Thermal Decomposition Kinetics of Ursodeoxycholic Acid Drug Crystal. Journal of Crystallization Process and Technology, 7, 85-90. doi: 10.4236/jcpt.2017.74006.

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