Model of Long-Term Vitamin A Deficiency in the Mammary Gland of Virgin Rats - Open Access Library Journal

OALibJ > Vol.4 No.9, September 2017

Open Access Library Journal

Volume 4, Issue 9 (September 2017)

ISSN Print: 2333-9705 ISSN Online: 2333-9721

Google-based Impact Factor: 0.73 Citations

Model of Long-Term Vitamin A Deficiency in the Mammary Gland of Virgin Rats ()

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DOI: 10.4236/oalib.1103887 730 Downloads 1,729 Views Citations

Author(s)

Miriam Ester Vasquez Gomez, Silvia Varas, Maria Sofia Gimenez

Affiliation(s)

Department of Biochemistry and Biological Sciences, Faculty of Chemistry, Biochemistry and Pharmacy, National University of San Luis, San Luis, Argentina.

ABSTRACT

Deficiency in vitamin A is an evil in underdeveloped countries where the minimum recommended intake is not achieved. This may have long-term implications on the health of the population. For this reason, it would be very useful to achieve an animal model where the different implications of this deficiency can be observed. This could lead to the formulation of future nutrition politics. The levels of retinoic acid and intermediary of the vitamin A pathway were studied; The levels of retinoic acid and intermediary of the vitamin A pathway (CRBP-1 and RARα) were studied. There was a decrease in the values of retinoic acid main indicator of deficiency of this vitamin in serum, liver and mammary gland and variation in expression of CRBP-1 and RARα mRNA in mammary gland. This model provides a tool for the study of the metabolism of vitamin A and its effects in different organs and especially in virgin mammary gland, where a deficiency is achieved despite being in a state of latency.

KEYWORDS

Retinoic Acid, Nutrition, CRBP-1, RARα

Share and Cite:

Gomez, M. , Varas, S. and Gimenez, M. (2017) Model of Long-Term Vitamin A Deficiency in the Mammary Gland of Virgin Rats. Open Access Library Journal, 4, 1-14. doi: 10.4236/oalib.1103887.

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