Author(s)

Lei Liu¹, Haoqi Wang¹, Haitao Sun², Chunyan Fu^1,3, Hongli Liu¹, Yuqing Sun¹, Xianghua Xu¹, Weiji Chen¹, Wenqiang Wu¹, Fuchang Li¹

¹Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Department of Animal Science and Technology, Shandong Agricultural University, Taian, China.
²Animal Husbandry and Veterinary Institute, Shandong Academy of Agricultural Sciences, Jinan, China.
³Poultry Institute, Shandong Academy of Agricultural Sciences, Jinan, China.

An experiment was conducted to investigate the effect of dietary pyridoxine on the gene expression of appetite-regulating peptides in the hypothalamus and gastrointestinal tract of rabbits. Thirty-two rabbits were randomly divided into 2 treatments for 8 weeks (16 replicates/group and 1 rabbit/replicate). The treatments were fed a basal diet (control, measured pyridoxine content is 4.51 mg/kg) and the basal diet with a pyridoxine supplementation at 10 mg/kg (pyridoxine, measured pyridoxine content is 14.64 mg/kg). The results showed that dietary pyridoxine did not significantly alter the mRNA levels of neuropeptide Y, agouti related peptide, pro-opiomelanocortin and cocaine, amphetamine regulated transcript, peptide YY and cholecystokinin in arcuate nucleus, peptide YY in jejunum and ileum, and cholecystokinin in duodenum, jejunum and ileum (P > 0.05). Compared with the control, the mRNA levels of corticotropin-releasing hormone and melanocortin 4 receptor in paraventricular nuclei and peptide YY in duodenum were significantly decreased after pyridoxine treatment (P < 0.05). In conclusion, the appetite genes of melanocortin 4 receptor and corticotropin-releasing hormone in paraventricular nuclei and peptide YY in duodenum are involved in the pyridoxine-caused hyperphagia.

Pyridoxine, Brain-Gut Peptides, Appetite Control

Liu, L. , Wang, H. , Sun, H. , Fu, C. , Liu, H. , Sun, Y. , Xu, X. , Chen, W. , Wu, W. and Li, F. (2017) Effects of Pyridoxine on Selected Appetite Regulating Peptides mRNA Expression in Hypothalamic PVN/ARC Nuclei and Gastrointestinal Tract Tissues. Advances in Bioscience and Biotechnology, 8, 273-282. doi: 10.4236/abb.2017.89020.