Effect of Initiation of Basal Insulin Glargine on Glycemic Control in Patients with Diabetes: Real Life Experience from Hong Kong ()
ABSTRACT
Introduction: To assess the changes in glycemic control after initiating or
switching to a basal insulin analogue in patients with diabetes mellitus. Methods:
A retrospective, observational analysis was conducted using electronic
data from a Hong Kong regional hospital. Data from adult patients with type
1 and 2 diabetes mellitus (T1DM and T2DM, respectively) who had been prescribed
with basal insulin glargine in 2008-2010, with recorded HbA1c levels
at the time of initiation, at 6 and 12 months thereafter, were analysed. Results:
Data from 106 eligible patients were analysed. Substantial reduction in HbA1c
and fasting sugar levels were reported in both T1DM (Δ HbA1c = 1.5%, Δ
FBG = 1.3 mmol/L p < 0.05) and T2DM (Δ HbA1c = 1.2%, Δ FBG = 2.9
mmol/L p < 0.05) patients after 12 months of therapy. A total of 42% of
T1DM and 26% of T2DM patients achieved HbA1c levels < 7.0%. After adjustment,
T2DM patients who were insulin naive achieved a statistically
greater HbA1c reduction (Δ = 1.7%) than those who previous treated with
premixed or basal bolus insulin (Δ = 0.3%) (p < 0.05). Percentage of patients
experiencing hypoglycaemia reduced from 69% to 62% in T1DM but increased
from 26% to 36% in T2DM patients. All hypoglycaemic episodes recorded
were either asymptomatic or mild and self-limiting. Only 4% of the
patients discontinued treatment at the end of 12 months. Conclusions: In
real life clinical practice, a single daily basal insulin analogue therapy provided
effective glycemic control with an acceptable risk of mild hypoglycaemia.
Share and Cite:
Yeung, C. , Fhkam, F. , Ngai, W. and Lau, I. (2017) Effect of Initiation of Basal Insulin Glargine on Glycemic Control in Patients with Diabetes: Real Life Experience from Hong Kong.
Journal of Diabetes Mellitus,
7, 108-120. doi:
10.4236/jdm.2017.73009.