Author(s)

James A. Mbah^*, Godfred A. Ayimele, Elvis N. Eyonganyoh, Emmanuel N. Nfor

Department of Chemistry, University of Buea, Buea, Cameroon.

A novel Schiff base, benzylmethyl-4-methyl-3-thiosemicarbazone (BMM) de-rived from benzylmethylketone and 4-methylthiosemicarbazide was synthe-sized and characterized by elemental analysis, spectroscopic methods (IR, ¹H NMR, ¹³C NMR) and physical means. The single crystal structure analysis of the Schiff base reveals that it crystallizes in a monoclinic system in the P2₁/c space group. BMM revealed moderate antibacterial activity on three bacterial strains with diameter zone of inhibition of 16 mm (E. coli), 14 mm (K. pneumonia) and 13 mm (S. epider-midis) compared with the standard drug, ciprofloxacin.

Benzylmethyl-4-Methyl-3-Thiosemicarbazone, Antibacterial Activity, Crystal Structure

Mbah, J. , Ayimele, G. , Eyonganyoh, E. and Nfor, E. (2017) Synthesis, Molecular Structure and Antibacterial Activity of Benzylmethyl-4-Methyl-3-Thiosemicarbazone. International Journal of Organic Chemistry, 7, 83-90. doi: 10.4236/ijoc.2017.72007.