Identification of Candidate Targeted Genes in Molecular Subtypes of Gastric Cancer - Journal of Biomedical Science and Engineering

JBiSE > Vol.10 No.5, May 2017

Journal of Biomedical Science and Engineering

Volume 10, Issue 5 (May 2017)

ISSN Print: 1937-6871 ISSN Online: 1937-688X

Google-based Impact Factor: 0.66 Citations h5-index & Ranking

Identification of Candidate Targeted Genes in Molecular Subtypes of Gastric Cancer ()

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Download as PDF (Size: 422KB) PP. 45-53

DOI: 10.4236/jbise.2017.105B005 1,408 Downloads 2,709 Views Citations

Author(s)

Wei Zeng^1,2, Ni-Ni Rao¹, Jie Zheng¹, Yong-Li Wan¹, Guang-Bin Wang¹, Zheng-Wen Li¹, Sang Li¹

Affiliation(s)

¹Department of Biomedical Engineering, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
²Department of Biomedical Engineering, School of Automation and Information Engineering, Sichuan University of Science and Engineering, Zigong, China.

ABSTRACT

Because of high heterogeneity, a further classification should be made for diagnosis and treatment in gastric cancer. Biomarkers selected in subtypes are important for precision medicine. Based on gene expression level, we constructed genome-wide co-expression networks for invasive, proliferative and metabolic subtype in gastric cancer respectively. The hierarchical clustering was used to get sub-networks, and hub gene sets of subtypes were got by analysis in sub-networks. Unique differential expression genes as candidate targeted genes in subtype were gained by a comparative analysis between subtypes. These genes may be helpful for improving diagnosis and therapy methods and developing new drug in gastric cancer.

KEYWORDS

Gastric Cancer, Molecular Subtype, Genome-Wide Co-Expression Network, Targeted Gene

Share and Cite:

Zeng, W. , Rao, N. , Zheng, J. , Wan, Y. , Wang, G. , Li, Z. and Li, S. (2017) Identification of Candidate Targeted Genes in Molecular Subtypes of Gastric Cancer. Journal of Biomedical Science and Engineering, 10, 45-53. doi: 10.4236/jbise.2017.105B005.

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[3]	Microtubule Engagement with Taxane Is Altered in Taxane-Resistant Gastric CancerTaxane Resistance in Gastric Cancer
	Clinical Cancer …, 2020

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