Hypoglycemic and Antioxidative Effects of Glossogyne tenuifolia on Streptozotocin-Nicotinamide-Induced Diabetic Rats - American Journal of Plant Sciences

AJPS > Vol.8 No.5, April 2017

Volume 8, Issue 5 (April 2017)

ISSN Print: 2158-2742 ISSN Online: 2158-2750

Google-based Impact Factor: 1.57 Citations

Hypoglycemic and Antioxidative Effects of Glossogyne tenuifolia on Streptozotocin-Nicotinamide-Induced Diabetic Rats ()

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DOI: 10.4236/ajps.2017.85077 1,568 Downloads 2,962 Views Citations

Author(s)

Ruoh-Yuh Wang^1,2, Jui-Hua Huang³, Guoo-Shyng Wang Hsu¹, Wan-Teng Lin⁴, Yi-Fa Lu^1,3*

Affiliation(s)

¹Department of Nutritional Science, Fu-Jen Catholic University, New Taipei City.
²Nutrition Department, Far Eastern Memorial Hospital, New Taipei City.
³PhD Program in Nutrition and Food Science, Fu-Jen Catholic University, New Taipei City.
⁴Department of Hospitality Management, Tunghai University, Taichung.

ABSTRACT

Glossogyne tenuifolia (GT) is the traditional herbal tea in Penghu Island, Taiwan. Recent research has shown that the active components in GT are potential inhibitors of α-glucosidase. The present study investigated that whether or not GT could improve the status of type 2 diabetes mellitus. Male Wistar rats aged eight weeks were induced to be hyperglycemic by subcutaneous injection of streptozotocin-nicotinamide (STZ-NA) and combination of high-fat diet (HFD). The animals were given GT extracts at the low dose or high dose, or the anti-diabetic drug (acarbose), in drinking water for 4 weeks. The results showed that hot water extracts from GT resulted in significantly decreases in fasting blood glucose at the 1^st and 2^nd weeks, fasting insulin levels at the 2^nd week, 1 hour postprandial blood glucose after the starch tolerance test on Day 23 and blood glucose levels after oral glucose tolerance test (OGTT) at the 60^th minute on Day 25. In addition, diabetic rats treated with GT extracts from hot water for 4 weeks displayed significantly decreased thiobarbituric acid reactive substances (TBARS) in the serum, liver and kidney, serum total cholesterol, fasting insulin levels and homeostasis model assessment for insulin resistance (HOMA-IR). Overall, these results demonstrate that the hot water extracts of GT might improve the progression of diabetes and decrease oxidative stress in STZ-NA-induced diabetic rats.

KEYWORDS

Glossogyne tenuifolia, Blood Glucose, Antioxidative, Diabetic Rats

Share and Cite:

Wang, R. , Huang, J. , Hsu, G. , Lin, W. and Lu, Y. (2017) Hypoglycemic and Antioxidative Effects of Glossogyne tenuifolia on Streptozotocin-Nicotinamide-Induced Diabetic Rats. American Journal of Plant Sciences, 8, 1170-1181. doi: 10.4236/ajps.2017.85077.

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