Residue Study for a Standardized Macleaya cordata Extract in Growing-Finishing Swine - Open Journal of Animal Sciences

OJAS > Vol.7 No.2, April 2017

Open Journal of Animal Sciences

Volume 7, Issue 2 (April 2017)

ISSN Print: 2161-7597 ISSN Online: 2161-7627

Google-based Impact Factor: 1.39 Citations h5-index & Ranking

Residue Study for a Standardized Macleaya cordata Extract in Growing-Finishing Swine ()

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Download as PDF (Size: 352KB) PP. 93-104

DOI: 10.4236/ojas.2017.72008 1,702 Downloads 3,088 Views Citations

Author(s)

Lu Zhao^1*, Ray A. Matulka¹, Sophie von Alvensleben², Mauro Morlacchini³

Affiliation(s)

¹Burdock Group, Orlando, FL, USA.
²Phytobiotics, Futterzusatzstoffe GmbH, Eltville, Germany.
³CERZOO Srl, Piacenza, Italy.

ABSTRACT

The aim of this study was to assess the effects of Sangrovit^®, a standardized preparation of Macleaya cordata extract (MCE), on the health status and retained residues in growing-finishing swine. A total of twelve growing-finishing swine (n = 6 for each group) were randomly divided into two groups and fed either a control feed or the control feed supplemented with 100 mg/kg Sangrovit^® (3.5 mg/kg MCE) for 28 days. The parameters for growth and health status were evaluated during the trial and after which the animals were slaughtered. Residual levels of MCE in swine organs and tissues were determined by measuring sanguinarine and chelerythrine levels by LC-MS/MS. The results showed no statistically significant differences in live weight, feed intake and average daily gain between the treatment and control groups. The feed supplemented with 100 mg/kg Sangrovit^® was well tolerated by the swine, with no adverse effects noted during the feeding period or in the necropsy results. Residue analysis indicated that levels of sanguinarine or chelerythrine were under the limit of detection in all the examined tissues and organs from the treated swine. This study demonstrates that Sangrovit^®, a standardized preparation of MCE when fed to growing-finishing swine for 28 days, at the level of 100 mg/kg in feed, does not result in sanguinarine or chelerythrine residues in the organs or tissues.

KEYWORDS

Macleaya cordata Extract, Swine, Sanguinarine, Tolerability, Residues

Share and Cite:

Zhao, L. , Matulka, R. , von Alvensleben, S. and Morlacchini, M. (2017) Residue Study for a Standardized Macleaya cordata Extract in Growing-Finishing Swine. Open Journal of Animal Sciences, 7, 93-104. doi: 10.4236/ojas.2017.72008.

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