Journal of Analytical Sciences, Methods and Instrumentation

Volume 7, Issue 1 (March 2017)

ISSN Print: 2164-2745   ISSN Online: 2164-2753

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Fitting Nonlinear Calibration Curves: No Models Perfect

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DOI: 10.4236/jasmi.2017.71001    2,354 Downloads   4,959 Views  Citations

ABSTRACT

The study of the calibration of a series of compounds of environmental concern (six perfluoroalkyl compounds (perfluorooctane sulfonic acid and five perfluoroalkyl carboxylic acids), three preservatives (methyl-, ethyl- and propylparabens) and the brominated flame retardant hexabromocyclododecane) by LC-MS/MS has been carries out, with a view to their simultaneous determination in samples of environmental interest. In some cases nonlinear calibration curves are obtained, but restricting the concentration range a linear model may be used to fit the data. Residual analysis has been performed in order to verify which models fit the data better, opting for a compromise decision given the apparent complexity of residuals plots. As Box states there are no perfect models (but models that work better than others).

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Martin, J. , Gracia, A. and Asuero, A. (2017) Fitting Nonlinear Calibration Curves: No Models Perfect. Journal of Analytical Sciences, Methods and Instrumentation, 7, 1-17. doi: 10.4236/jasmi.2017.71001.

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