The objectives of this study were to evaluate growth, yield and nutrients removal of five cassava cultivars planted by different planting methods in late rainy season of northeastern Thailand. A split plot design was used in this study. The planting methods (vertical and horizontal) were assigned as main-plots. Cassava cultivars (Rayong-7, Rayong-11, Rayong-72, Huaybong-80 and E-dum) were assigned as sub-plots with four replications. Results showed that vertical planting gave significantly higher fresh storage root yield than those of horizontal planting, across five cassava cultivars. The cultivar Rayong-7 produced maximum fresh storage root yield across two planting methods, but not significantly different from Rayong 11, Huaybong 80 and Edum cultivars. Irrespective of nutrient removal, N, P and K removed ranges from 2.9 - 3.6, 0.8 - 1.3 and 5.3 - 7.9 kg per ton fresh root weight, respectively depending on cassava cultivar. The cultivar Rayong-7 removed the highest quantities of N, and the cultivar Rayong-11 removed maximum of P and K in the present study. Regardless of nutrient removal at different plant parts; N, P and K removed maximum quantities in leaf, stem and storage root, respectively. Planting method had no significant effect on N and P removal, but significant effect on K removal. The vertical planting removed K higher than those of horizontal planting.