Author(s)

Ning Cao^1*, Eric C. Ford¹, Matthew J. Nyflot¹, Ralph P. Ermoian¹, Nicole W. Pelly², Lori Young¹, Kristi Hendrickson¹

¹Department of Radiation Oncology, University of Washington, Seattle, WA, USA.
²Department of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA, USA.

Purpose: To share our clinical experience of an optimized and comprehensive pediatric TBI technique. Methods and Materials: Through the use of incident learning, safety-critical areas were identified in our procedure for total body irradiation (TBI) for pediatric patients under anesthesia for bone-marrow transplant. The previous procedure lacked flexibility to accommodate various requests from the anesthesia team due to the wide range of patient sizes. To address this issue and to improve the process overall, we updated our procedure for TBI simulation, dosimetry planning, patient setup during treatment, and in vivo dosimetry. A simulation form was redesigned with additional detailed instructions and documentation requirements. The dose calculation procedure was reformulated to remove dependence on setup variations. Tissue compensation determination and therefore dose uniformity were improved by introducing rigorous calculation methods. Calculations were performed on 28 previously-treated patients to compare the dose uniformity using the new versus previous methods. Results: The new procedures improve interdepartmental communication, simplify the workflow, decrease the risk of treating patients in a setup that differs from that used during the simulation, and reduce dose heterogeneity. The new compensator design significantly improved patient dose uniformity: 0.8% ± 0.4% (new method) vs. 4.2% ± 2.3% (previous method) (p < 0.01). Conclusion: A near-miss incident reporting system was used to improve the safety and quality of pediatric TBI procedures under anesthesia.

Pediatric Total Body Irradiation Simulation, Dosimetry, Treatment Setup, Continuous Safety Improvement (CSI)

Cao, N. , Ford, E. , Nyflot, M. , Ermoian, R. , Pelly, N. , Young, L. and Hendrickson, K. (2016) TBI Technique Improvements for Anesthetized Pediatric Patients Based on Near-Miss Incident Reporting. International Journal of Medical Physics, Clinical Engineering and Radiation Oncology, 5, 270-280. doi: 10.4236/ijmpcero.2016.54027.