Advances in Microbiology

Volume 6, Issue 9 (August 2016)

ISSN Print: 2165-3402   ISSN Online: 2165-3410

Google-based Impact Factor: 1.18  Citations  h5-index & Ranking

Effects of Cinnamaldehyde, Ocimene, Camphene, Curcumin and Farnesene on Candida albicans

HTML  XML Download Download as PDF (Size: 4343KB)  PP. 627-643  
DOI: 10.4236/aim.2016.69062    2,261 Downloads   4,585 Views  Citations

ABSTRACT

Efficacy of five plant molecules against thirty three clinical isolates and two standard strains of C. albicans, differentially susceptible to fluconazole (FLC) is tested in this study. Effect on biofilm (adhesion, development and maturation) formation, morphogenesis and synergy with fluconazole (FLC) against a FLC resistant strain of Candida albicans ATCC 10231 is also evaluated. All the plant molecules tested were equally effective against isolates and strains of C. albicans (N = 35) tested in this study. Cinnamaldehyde was found most effective against planktonic growth followed by ocimene. Both the molecules exhibited fungicidal activity and killed 99.9% of inoculum within 80 and 20 min of exposure respectively at 0.62 mM and 176.8 mM concentrations. Curcumin (5 - 20 mM), camphene (8 - 32 mM) and farnesene (25 - 100 mM), although inhibited planktonic growth, were fungistatic. All the five plant molecules tested in this study inhibited morphogenesis significantly and exhibited considerable activity against biofilm formation. Inhibition of biofilm was found to be stage specific i.e. efficacy was more against adhesion followed by developing and mature biofilm. Plant molecules tested exhibited excellent synergy with fluconazole. However FIC index values 0.155, 0.062 and 0.046 indicate that ocimene was the most effective synergistic molecule inhibited planktonic growth, developing biofilm and mature biofilm growth respectively at very low concentrations. This is the first report of anti-Candida activity of three terpenoids viz. ocimene, farnesene and camphene against planktonic & biofilm growth, morphogenesis as well as synergy with FLC. Plant molecules tested in this study may find use in antifungal chemotherapy individually and or in a combination with FLC.

Share and Cite:

Thakre, A. , Mulange, S. , Kodgire, S. , Zore, G. and Karuppayil, S. (2016) Effects of Cinnamaldehyde, Ocimene, Camphene, Curcumin and Farnesene on Candida albicans. Advances in Microbiology, 6, 627-643. doi: 10.4236/aim.2016.69062.

Cited by

[1] Chemical Profile, Anti-Microbial and Anti-Inflammaging Activities of Santolina rosmarinifolia L. Essential Oil from Portugal
Silva, MJ Gonçalves, A Silva, C Cavaleiro… - Antibiotics, 2023
[2] Menthol Inhibits Candida albicans Growth by Affecting the Membrane Integrity Followed by Apoptosis
Evidence-Based …, 2022
[3] Composition and antimicrobial activity of Pastinaca sativa subsp. sativa, P. sativa subsp. urens and P. hirsuta essential oils
Journal of Essential …, 2022
[4] CHEMICAL PROFILING AND ANTIMICROBIAL POTENTIAL OF VOLATILE LEAF OILS ISOLATED FROM THREE MANGROVES GROWING IN RIVERS STATE …
Journal of Chemical …, 2022
[5] Chemical Composition and Biological Activities of Prangos ferulacea Essential Oils
Molecules, 2022
[6] Curcumin affects function of Hsp90 and drug efflux pump of Candida albicans
Frontiers in Cellular …, 2022
[7] Plant oils: From chemical composition to encapsulated form use
2021
[8] Urease Inhibitory Kinetic Studies of Various Extracts and Pure Compounds from Cinnamomum Genus
2021
[9] In Vitro and in Vivo Biological Investigations of Camphene and Its Mechanism Insights: A Review
2021
[10] Determination of Terpenoid Profile in Dry Cannabis Flowers and Extracts Obtained from Different Cannabis Varieties
Journal of …, 2021
[11] In-silico study of some natural compounds used as antifungal agents against Candida albicans
2020
[12] Genetic and proteomic analysis of Candida albicans biofilm
2020
[13] Terpenes/Terpenoids in Cannabis: Are They Important?
2020
[14] Phytochemical Profile, Antimicrobial and Antioxidant Activities of Cistus clusii Essential oil From Algeria
Current Bioactive …, 2020
[15] Influencia de la madurez en el rendimiento y las propiedades fisicoquímicas del aceite esencial del fruto de naranjo tipo valencia
2019
[16] Effectiveness of five flavored Tunisian olive oils on Anisakis larvae type 1: application of cinnamon and rosemary oil in industrial anchovy marinating process
2019
[17] Application of a multisystem coating based on polymeric nanocapsules containing essential oil of Thymus vulgaris L. to increase the shelf life of table grapes (Vitis …
2019
[18] An investigation of chemical composition and antimicrobial activity of essential oils extracted from Aeollanthus and Plectranthus species
2019
[19] Curcumin-Loaded Liquid Crystalline Systems for Controlled Drug Release and Improved Treatment of Vulvovaginal Candidiasis
Molecular Pharmaceutics, 2018
[20] Secondary metabolites, secretory structures and biological activity of water celery (Apium nodiflorum (L.) Lag.) growing in central Italy
Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology, 2018
[21] Effectiveness of Phytoactive Molecules on Transcriptional Expression, Biofilm Matrix, and Cell Wall Components of Candida glabrata and Its Clinical Isolates
ACS Omega, 2018
[22] Formulation, stability study, and pre‐clinical evaluation of a vaginal cream containing curcumin in a rat model of vulvovaginal candidiasis
Mycoses, 2018
[23] Antibacterial and antibiofilm activity of cinnamaldehyde against carbapenem-resistant Acinetobacter baumannii in Egypt: In vitro study
2018
[24] Anti-Yeast Activity of Cinnamaldehyde, Eugenol and Linalool
World Journal of Research and Review, 2017

Journals Menu
Follow SCIRP
Contact us
+1 323-425-8868
customer@scirp.org
WhatsApp +86 18163351462(WhatsApp)
Click here to send a message to me 1655362766
Paper Publishing WeChat

Copyright © 2024 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.