Author(s)

Andrey N. Glushkov^1，2*, Elena G. Polenok¹, Valentin A. Ustinov¹

¹Federal State Scientific Institution, Federal Research Centre Coal and Coal Chemistry, Siberian Branch of the Russian Academy of Sciences, Institute of Human Ecology, Kemerovo, Russia.
²Federal State Educational Institution of Higher Professional Education, Kemerovo State University, Kemerovo,Russia.

It was supposed that lung and breast cancer risks significantly increased when the levels of serum immunoglobulins A antibodies against benzo[a]pyrene and estradiol increased together, but did not separately. However, the cancer risks dramatically decreased when the levels of immunoglobulins A against progesterone elevated separately or together with immunoglobulins A against benzo[a]pyrene and estradiol. So, immunoglobulins A against benzo[a]pyrene and immunoglobulins A against estradiol acted as co-initiator and co-promoter in developing cancer scenario, but immunoglobulins A against progesterone acted along or conjointly with immunoglobulins A against benzo[a]pyrene and estradiol as strongly inhibitor in human carcinogenesis. Also it was suggested the precise mechanism of carcinogenesis modulation using anti-idiotypic antibodies against estradiol and progesterone through their membrane steroid receptors.

Benzo[a]pyrene, Estradiol, Progesterone, Antibody, Anti-Idiotypic Antibody, Immunoglobulins A, Polycyclic Aromatic Hydrocarbons, Immunology, Lung Cancer, Breast Cancer, Cancer Risks

N. Glushkov, A. , G. Polenok, E. and A. Ustinov, V. (2016) Immunomodulation of Human Carcinogenesis by the Blood Serum Antibodies against Benzo[a]pyrene, Estradiol and Progesterone. Open Journal of Immunology, 6, 67-72. doi: 10.4236/oji.2016.63007.