Author(s)

Gaddas Meriem^1*, Chaouache Nesrine¹, Ajina Mounir², Tabka Zouhair¹, Zaouali Ajina Monia¹

¹Laboratory of Physiology and Functional Explorations, Faculty of Medicine “Ibn el Jazzar”, University of Sousse, Tunisia.
²Unity of Reproduction Medicine, “Farhat Hached” University Hospital, Sousse, Tunisia.

Objectives: in case of Polycystic Ovary Syndrome (SOPK), predicting ovarian response before undertaking risky in vitro fertilization (IVF) proceeds is crucial. Sex Hormone Binding Globulin (SHBG) is introduced in literature as an interesting indicator of follicle’s maturation and quality. The aim of this study was to investigate whether serum SHBG levels are related to fertilization outcomes in SOPK women undergoing IVF procedures. Methods: in a prospective cohort study, we enrolled 61 SOPK women and 91 matched group of infertile women. All of them were undergoing FIV/ICSI proceeds. SHBG levels were performed in peripheral blood samples as well as others hormones determination. Results: we noted significant differences between our study group of SOPK patients and the Control group concerning the characteristics of the ovarian response to gonadotrophins administration and concerning the profile of biological proceeds’ outcomes. But no significant correlation between SHBG and FIV/ICSI outcomes was found either in SOPK or in Control group. Conclusions: our study provides evidence that SHBG can’t be considered as a predictor of IVF outcomes because production of this steroid-binding protein depends on many parameters such as metabolic disorders frequently associated with SOPK.

SOPK, FIV, SHBG

Meriem, G. , Nesrine, C. , Mounir, A. , Zouhair, T. and Monia, Z. (2016) Sex Hormone Binding Globulin as a Predictor of in Vitro Fertilization Outcomes in Polycystic Ovary Syndrome: Our Results. Open Journal of Obstetrics and Gynecology, 6, 404-410. doi: 10.4236/ojog.2016.67053.