Author(s)

Mohammad Al-Masum^*, Linda Quinones, Laurance T. Cain

Department of Chemistry, Tennessee State University, Nashville, TN, USA.

Anhydrous Cu(OAc)₂ mediated efficient protocol has been developed in the area of C-O coupling from potassium aryltrifluoroborates and aliphatic amino alcohols such as β-hydroxy, γ-hydroxy, and δ-hydroxy amines. The scope of this transformation focuses on direct O-arylation and O-styrylation. The reaction vial loaded with reactants under argon atmosphere is microwaved at 140°C for 30 min to furnish the corresponding cross-coupling product, amino ethers, in good yields.

Hydroxylamine, Amino Ether, O-Arylation, O-Styrylation, Microwave

Al-Masum, M. , Quinones, L. and Cain, L. (2016) Microwave Application and Anhydrous Cu(OAc)₂ Mediated O-Arylation of Aliphatic Amino Alcohols. International Journal of Organic Chemistry, 6, 100-106. doi: 10.4236/ijoc.2016.62011.