Author(s)

Akam A. Saeed^1,2*, Zana A. Mohammed^1,2,3, Rebeen R. Saeed^1,2

¹Shar Teaching Hospital of Sulaimania, Sulaimania, Iraq.
²General University Teaching Hospital of Sulaimania, Sulaimania, Iraq.
³School of Medicine, University of Sulaimania, Sulaimania, Iraq.

Neuromyotonia is a neuromuscular hyperexitability disorder characterized by muscle stiffness caused by continuous muscle fiber activity. It is an immune mediated disorder with elevated antibody level against presynaptic, voltage gated potassium channels, either as isolation or as a paraneoplastic process. Symptoms usually include muscle twitching during rest (myokymia), cramps, peudomyotonia (delayed relaxation), increased sweating, and sometimes motor weakness. In this case report, we present a seventy-two years old man who presented with pain in both thighs for one month. It gradually became worse to involve feet and chest. His brain CT scan showed features of brain atrophy. EMG showed fasciculation along neuromyotonic discharges with characteristic wave in frequency and amplitude typical of Isaacs’ syndrome. Potassium channel antibodies were very high. Diagnosis of Isaacs’ syndrome was made. He was followed up for two months with treatment by three-day course of methyl prednisolone followed by oral steroid and methotrexate with much improvement. This is the first case of Isaacs’ syndrome in Kurdistan.

Issacs, Syndrome, Myokymia, Neuromyotonia, Neurology, Motor, Disorders, Hyperexcitability

Saeed, A. , Mohammed, Z. and Saeed, R. (2016) Case Report: A 72 Years Old Man with Isaacs’ Syndrome: A Rare Entity with Different Outcomes. World Journal of Neuroscience, 6, 82-84. doi: 10.4236/wjns.2016.62010.