Author(s)

Mohsen M. Zareh^1,2*, Mohammed I. ALahmdi¹, Ali A. Keshk¹

¹Department of Chemistry, Faculty of Science, Tabuk University, Tabuk, Saudi Arabia.
²Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt.

The construction and performance characteristics of a novel (diphenhydramine) DPH CC-sensor based on DZCE were reported in this work. The CC-membrane was prepared by incorporating of (diazacrown ether) DZCE and/or (tetraflorophenyl borate) TFPB into a plasticized poly(vinyl chloride) membrane. The CC-sensor revealed a Nernstian behavior over a DPH-concentration range (9.1 × 10^-3 - 6.3 × 10^-7 mol ·L^-1), and relatively low detection limit (1 × 10^-7 mol ·L^-1). The potentiometric response was independent on the pH of the solution in the range of 7 - 10. The DPH-CC showed a very short response time (<5 s). It showed good selectivity towards different cations and pharmaceutical compounds. The relative selectivity coefficient was applied for evaluation of the selectivity properties of the DPH-CC. The DPH-CC was used successfully for determination of DPH in its samples. The found recovery range was 95% - 98.5%, and the standard deviation value ranged between 0.13 - 0.42. The DPH-CC facilitates the analysis of DPH directly without pretreatment and it can be built-in as a detector in chromatographic apparatus. It can be used as a tool for on-line monitoring of the drug levels.

Compact Cell, Diphenhydramine Determination, Drug Sensor

Zareh, M. , ALahmdi, M. and Keshk, A. (2016) Diphenhydramine Compact-Cell Sensor. Journal of Sensor Technology, 6, 1-10. doi: 10.4236/jst.2016.61001.