The Results Observation on Adjuvant Chemotherapy with Microwave Hyperthermia and Stereotactic Radiotherapy in Retreated Elderly Patients with Advanced (III/IV Stage) Lung Cancer ()
ABSTRACT
Objective: To evaluate the significance
of adjuvant chemotherapy and radiotherapy (Gamma-knife) in the elderly patients
with retreated advance lung cancer. Methods 83 patients (age 50 to 81 years)
with retreating advanced (III/IV stage) lung cancer were divided into three
groups according to patients received treating by different methods. The cases
were treated by synchronous chemo-radiotherapy (A group), sequentially chemo-radiotherapy
(B group) and continuous systematized chemotherapy alone (C group). The
systemic 3-dimensional orientation apparatus was used in radiotherapy. The
chemotherapy regimen in combined radiotherapy was given by common first line regimen
on lung cancer. The regimen of chemotherapy combated with whole body
hyperthermia by using micro-wave on abodeman about 2 or 3 line was used in C
group only. Results: The overall responses rates (RR) of A, B and C groups were
17.1%, 11.5% and 31.8%, but it was non-significance difference (P > 0.05).
Overall responses rates (RR) of III and IV stage groups were 18.2% and 20.0%.
The average overall survival time (OS) and median survival time (MST) of the
patients treated by chemotherapy (C group) were highest about 14.2 and 9.3 months
(respectively at A group 6.7 and 6.0 months. P < 0.01), in which B group was
longer than A group (P < 0.05), and 95.5% CI value was not overlap. The
total survival time of postoperative patients was longer in the various groups
by different treated than that in non-operations. Conclusion: The rates (RR) of
III and IV stage groups were non-significance difference. The higher of ORR, OS
and MST in a few patients of re-treated advanced lung cancer was presented in
case with treated by continuous system chemotherapy. There were survival
superiority in initial postoperative patients groups by different treated. It
is a profitable and effect treatment that the pure reasonable systemic
chemotherapy was used for elderly case with advanced retreated lung cancer.
Share and Cite:
Yu, X. , Li, X. , Dong, G. , Yu, W. , Wang, J. and Xiong, Y. (2016) The Results Observation on Adjuvant Chemotherapy with Microwave Hyperthermia and Stereotactic Radiotherapy in Retreated Elderly Patients with Advanced (III/IV Stage) Lung Cancer.
Journal of Biosciences and Medicines,
4, 75-78. doi:
10.4236/jbm.2016.43013.
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