Author(s)

Peipei Zhang¹, Tingting Liu², Xuejiao Xu², Shuyu Liu^1*, Dongying Chen^2*

¹School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, China.
²Laboratory of Pharmaceutical Analysis, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

Two simple and rapid analytical methods (DSC and ¹H-NMR), are proposed for determination of meclofenoxate in meclofenoxate hydrochloride for injection. DSC thermogram is recorded without any sample pretreatment. The response linearity is ensured by linear determination factors R², which is 0.9982. The recoveries of meclofenoxate hydrochloride in sterile powder for injection are from 98.3% to 102.3% (n = 3). The quantitative ¹H-NMR is quick and simple to use. The quantitation of meclofenoxate is reproducible and the relative standard deviation is 1.0%. The accuracy of two methods is validated by comparison with the results obtained by HPLC. The results show that the two methods are capable of quantifying the content of meclofenoxate in meclofenoxate hydrochloride for injection.

Meclofenoxate Hydrochloride, DSC, ¹H-NMR, Analysis

Zhang, P. , Liu, T. , Xu, X. , Liu, S. and Chen, D. (2016) Determination of Meclofenoxate Content in Meclofenoxate Hydrochloride for Injection by DSC and ¹H-NMR. American Journal of Analytical Chemistry, 7, 92-98. doi: 10.4236/ajac.2016.71009.