Author(s)

Peipei Zhang, Shuyu Liu^*

College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, China.

In this article, we reported that carmofur could be induced by some solvent to produce conformational alteration. Ultraviolet (UV) spectra were used to study the conformation alteration of carmofur. Upon the addition of acid in the some solvent, UV spectroscopy of carmofur could change gradually. When base was added to this system, UV spectroscopy of carmofur could return to the original state, and the change process was reversible. The variable temperature 1H and 13C-NMR spectrum were used to testify that temperature did not have any effect on the conformation alteration of carmofur in Acetonitrile: Trifluoroacetic-acid (9:1). These two conformers of carmofur were structurally stable in Acetonitrile: Trifluoroacetic-acid (9:1).

Solvent-Induced, Carmofur, Conformation, UV Spectra

Zhang, P.P. and Liu, S.Y. (2016) Solvent Effects on the UV Absorption Spectrum of Carmofur. Detection, 4, 25-31. doi: 10.4236/detection.2016.41004.