Author(s)

A. V. Kovner^*, O. V. Potapova, V. A. Shkurupy, A. M. Shestopalov

Federal State Budgetary Scientific Institution Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia.

There is an annual increase of influenza-related SARI cases in winter months. Despite the high relevance of this problem, influenza pathogenesis and the role of surfactant system and its SP-A (surfactant protein A) enzyme in antiviral defense remain poorly understood. SP-A activates macrophage M1 polarization and triggers an antiviral response due to the activation of T-cells and dendritic cells. Therefore, surfactant system is an important element of infection protection and a promising therapeutic target.

Influenza A (H1N1) Virus, Pulmonary Surfactant system, SP-A, M1/M2 Macrophages, Antiviral Defense

Kovner, A. , Potapova, O. , Shkurupy, V. and Shestopalov, A. (2016) Morphofunctional Characteristics of Pulmonary Surfactant System and Its Effect on Immune Cells in Influenza A (H1N1) Pathogenesis. Open Journal of Pathology, 6, 1-7. doi: 10.4236/ojpathology.2016.61001.