Inter-Toe Cracks: A Cosmetic Response versus Excipient. Efficacy and Tolerance Evaluation ()
Author(s)
Adeline Jeudy1,2,3,
Thomas Lihoreau1,2,3,
Ferial Fanian1,2,3,
Rafat Messikh1,2,3,
Christine Lafforgue1,2,3,
Philippe Humbert1,2,3*
Affiliation(s)
1Research and Studies Center on the Integument (CERT), Department of Dermatology, Besancon University Hospital, Besancon, France.
2Clinical Investigation Center (CIC Inserm 1431), Besancon University Hospital, Besancon, France.
3Inserm UMR1098, FED4234 IBCT, Besancon University Hospital, Besancon, France.
ABSTRACT
A randomized, monocentric, double-blind, intra-individual
excipient-controlled comparative study was performed to evaluate the efficacy
and tolerance of an active peptide (laminin 5 fragment [LN-5]) formulated in
cosmetic balm, versus excipient in inter-toe cracks. Two products were tested
on 10 healthy volunteers. Each of them suffered from this particular
superficial wound characterized by a peeling off a skin tab between at least
two inter-toe spaces. The duration of this study belonged of 28 days with an
intermediate visit to D14. Initial and outcome evaluation was performed using a
4-grade-scale depending on the severity of the inter-toe cracks. Tolerance and
healing were assessed using macrophotographs. At D14 and D 28, the difference
of cure between the 2 treatments was in favor of the peptide active product. The
clinical score showed a best efficiency of the active compared with the
excipient; indeed a significant difference between D28 and D0 was observed for
the active ingredient. Active product repairs more quickly inter-toes cracks
than the excipient and we noted the complete disappearance of the “severe” and “moderate”
stages from the 14th day. This study showed clearly a fast (in 14
days) and beneficial effect of the application of LN-5 compared with the
excipient, on the cutaneous repair of inter-toes cracks. Since LN-5 fragment is
capable of producing immediate biological activity and reinforcing the dermal-epidermal
junction, it can accelerate tissue repair.
Share and Cite:
Jeudy, A. , Lihoreau, T. , Fanian, F. , Messikh, R. , Lafforgue, C. and Humbert, P. (2015) Inter-Toe Cracks: A Cosmetic Response versus Excipient. Efficacy and Tolerance Evaluation.
Journal of Cosmetics, Dermatological Sciences and Applications,
5, 291-296. doi:
10.4236/jcdsa.2015.54035.
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