Increased Spot Urinary Protein-to-Creatinine Ratio Can Be a Useful Predictor of Preeclampsia ()
ABSTRACT
Objectives: Preeclampsia is a major cause of maternal and perinatal
morbidity and mortality. Early diagnosis of preeclampsia is important to help
patients with preeclampsia. However, 24-hour urine collection is the gold
standard diagnostic method at present. Recently, the spot urinary protein-to-creatinine
ratio (P/C ratio) has been used to detect suspected preeclampsia, because it
can be used to estimate the amount of 24-hour urinary protein. The aim of this
study is to investigate whether an increase in P/C ratio precedes emergence of
hypertension among inpatients with preeclampsia. Method: The P/C ratio in
normotensive (systolic blood pressure < 140 mm Hg and diastolic blood
pressure < 90 mm Hg) pregnant women was measured during regular prenatal
checkups and in inpatients with preeclampsia between April 1, 2013 and March
31, 2014. Results: We included in this study 4074 normotensive pregnant women.
The 95th percentile values for the trimester of pregnancy were 0.100, 0.157,
and 0.195, respectively. The 95th percentile value for each trimester of
pregnancy and gestational age were determined as criterion (Y) and predictive
variables (X), respectively. In a simple regression analysis, the regression
line was calculated as Y = 0.0035X + 0.0849 (R2 = 0.9913).
Twenty-one women were diagnosed with preeclampsia. In 14 patients with
preeclampsia, the timing of the increase in P/C ratio to higher than the
regression line preceded the emergence of hypertension. Six patients had no
data on P/C ratio, and 1 patient had hypertension before the increase in P/C
ratio. Conclusions: An increase in P/C ratio to higher than the 95th percentile
value can be a useful predictor of preeclampsia.
Share and Cite:
Nishimura, M. , Nakashima, A. , Kushimoto, T. , Goto, M. , Yoshida, S. , Sato, O. , Shikado, K. and Ogita, K. (2015) Increased Spot Urinary Protein-to-Creatinine Ratio Can Be a Useful Predictor of Preeclampsia.
Open Journal of Obstetrics and Gynecology,
5, 808-812. doi:
10.4236/ojog.2015.514114.
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