Author(s)

Abdulmonim A. Alqasim¹, Sami H. Hammadi², Ghazi A. Bamagous³, Essam Eldin M. Noureldin⁴, Hussam H. Madi⁵

¹Department of Physiology, Faculty of Medicine, Umm-Alqura University, Makkah, Saudi Arabia.
²Department of Internal Medicine, Faculty of Medicine, Umm-Alqura University, Makkah, Saudi Arabia.
³Department of Pharmacology & Toxicology, Faculty of Medicine, Umm-Alqura University, Makkah,Saudi Arabia.
⁴Department of Biochemistry, Faculty of Medicine, Umm-Alqura University, Makkah, Saudi Arabia.
⁵Department of Pathology, Faculty of Medicine, Umm-Alqura University, Makkah, Saudi Arabia.

Objectives: The aim of this study is to compare the efficacy of the anti-angiotensinic drug, ramipril and irbesartan on the vascular protection of kidneys of streptozotocin (STZ)-induced diabetic rats (DR). Methods: 110 male albino rats were divided into 7 main groups. Group-1 (10 normal control rats; NC). Group-2 (10 rats) was injected intra-peritoneally with STZ (Diabetic Rats; DR). Group-3 (10 DR) is controlled by insulin. Groups 4 to 7 (20 DR), each is subdivided into two subgroups that received either low or high dose of ramipril or irbesartan with or without insulin. Two months post treatment, rat-tail blood was collected to measure: Fasting blood sugar, HbA1c, total serum proteins, albumin and lipid profiles. Urine was collected to measure albuminuria. Kidneys were isolated for histopathological study. Results: Biochemically, both ramipril and irbesartan (without insulin) lowered albumin concentration in urine samples especially at high doses. Histopathologically, there is no beneficial response of both drugs without insulin. Combination of insulin together with either drug has beneficial effects biochemically and histopathologically at high doses. Low dose irbesartan only has renoprotective effect in DR treated with insulin. The other biochemical parameters showed negligible response to both drugs. Conclusion: Low dose irbesartan and high doses of both drugs have renoprotective effect in DR treated with insulin.

Diabetic Nephropathy, Albuminurea, Ramipril, Irbesartan

Alqasim, A. , Hammadi, S. , Bamagous, G. , Noureldin, E. and Madi, H. (2015) Low Dose Irbesartan Has a Renoprotective Effect as High Dose Ramipril in Diabetic Rats Treated with Insulin. Open Journal of Endocrine and Metabolic Diseases, 5, 149-161. doi: 10.4236/ojemd.2015.511019.