Comparative Study of Imaging Characteristics of I-125 Imaging Using the Siemens Inveon Scanner and Siemens Symbia TruePoint ()
Author(s)
Young Jun Kim1,
Ilhan Lim1,2*,
A Ram Yu1,
Byung Il Kim1,2,
Chang Woon Choi1,2,
Sang Moo Lim1,2,
Jin Su Kim1,3,4*
Affiliation(s)
1Molecular Imaging Research Center, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul, Korea.
2Department of Nuclear Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul, Korea.
3Korea Drug Development Platform Using Radio-Isotope (KDePRI), Seoul, Korea.
4Radiologcial and Medico-Oncological Sciences, University of Science and Technology (UST), Seoul, Korea.
ABSTRACT
Objective: Although Iodine-125 (125I) has been widely used for in vitro studies because of its relatively long half-life (60.1 days), 125I imaging is limited because of its low energy (27 - 35 keV), even in an animal-dedicated system. In this study, imaging characteristics of 125I were assessed using a small animal-dedicated imaging system and clinical scanner. Methods: Using the Siemens Inveon and Siemens Symbia TruePoint systems, imaging characteristics such as resolution, sensitivity, and image quality were compared. Mouse high resolution (MHR-0.5), mouse general purpose (MGP-1.0), and mouse high sensitivity (MHS-2.0) collimators were used for the Inveon scanner, and low energy high-resolution (LEHR) and low energy all-purpose (LEAP) collimators were used for the Symbia TruePoint. For animal imaging, 16.8 MBq of 125I was administered to BALB/c mice intravenously, and the planar image and single-photon emission computed tomography (SPECT) were obtained using both scanners. Results: The resolution of 125I for the Inveon scanner was 3.98 mm full width at half maximum (FWHM) at a 30-mm distance with the MHR-0.5 collimator, and the value of Symbia scanner was 8.72 mm FWHM at a 30-mm distance with the LEHR collimator. The sensitivity of 125I for the Inveon scanner was 21.87 cps/MBq, and the value for the clinical scanner was 30.55 cps/MBq. The planar images of mice were successfully obtained at the level of evaluating specific binding in both scanners. Conclusion: 125I small animal imaging can be achieved with a clinical scanner. This result may enhance the utilization of 125I small animal imaging using a clinical scanner.
Share and Cite:
Kim, Y. , Lim, I. , Yu, A. , Kim, B. , Choi, C. , Lim, S. and Kim, J. (2015) Comparative Study of Imaging Characteristics of I-125 Imaging Using the Siemens Inveon Scanner and Siemens Symbia TruePoint.
Journal of Biomedical Science and Engineering,
8, 674-683. doi:
10.4236/jbise.2015.810064.
Cited by
No relevant information.